KJM314 Applied Organic Analytical Chemistry

The course will focus on various applications for organic analytical chemistry:

• HPLC: for purification and isolation of organic compounds
• GC/MS and GC/ECD: within environmental chemistry and pollution
• LC/MS, GC/MS and GC/FID: for product control in technical applications and synthesis
• LC/MS and GC/MS: for purification and product control within drug and food production.

Quantitative standard methods like GC/MS, as well as purification methods like column chromatography and SPE, Silica based, and Alumina-based chromatography will be applied and evaluated. Critical method validation and quality control will be integrated into both lectures and practice.

The teaching goals of the course reflect the UN Sustainable development goals 1, 3, 4, 6, 7, 9, 11, 12, 13, 14 & 15

GENERAL: Practical guidance is provided into the analytical organic chemistry as a versatile tool in a variety of applications spanning from technical control, product control to pharmaceutical application, food safety, environmental chemistry, organic pollutant quantification and medical/ health-related applications.

EXPECTED OUTCOME: After completion, the candidates should have knowledge of, and be familiar with, the various analytical techniques used for sample purification, method validation and quantitative analysis using a variety of chromatographic separation and detection techniques, including mass spectrometry, UV-VIS detection etc. Interpretation of chromatograms, quality check and quantification procedures are central topics.

EXPECTATIONS: Students will become familiar with the validation of methods for specific applications and will be able to select appropriate methods for a specific application within the field of organic analytical chemistry. Good knowledge of chromatographic principles, hyphenation to different detectors is a prerequisite for the course. Furthermore, the capacity for independent and self-initiated learning and active practical contribution to the lgroup work in the laboratry is expected. The student is able to perform the preparations, techniques and analyses employed in the course. The student masters the instruments and equipment used in the course.