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Kjetil Hodne

Kjetil Hodne

Forsker

  • Faggruppe fysiologi

I obtained my PhD in biology 2013. Currently, I'm working as a researcher in professor Finn-Arne Weltzien's group.  My research focus is on neuroendocrine regulation of sexual maturation and puberty. In particular, I'm investigating mechanisms behind the differential control of the two pituitary hormones follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh). These two hormones are responsible for stimulating the gonads in producing egg and sperm. The secretion of Fsh and Lh is triggered by an increased level of calcium ions (Ca2+) in the cell’s cytosol. Ca2+ can either be released from stores inside the cell itself or enter the cell from outside. One of the main aims is to understand how the two cell types utilize the different Ca2+ stores during hormone secretion. To decipher these complex events I combine patch-clamp electrophysiology with Ca2+ imaging. In addition, I'm using flash photolysis technique. This technique allows us to activate a variety of molecules like Ca2+ using high-intensity light or laser and thereby control cellular events in both time and space. 

ORCID

CV

  • Publikasjoner

    Liste med publikasjoner fra min forskning. (Cristin)

     

    2018
    1. Ager-Wick, Eirill; Hodne, Kjetil; Fontaine, Romain; von Krogh, Kristine; Haug, Trude; Weltzien, Finn-Arne. 
    Preparation of a High-quality Primary Cell Culture from Fish Pituitaries. Journal of Visualized Experiments 2018 ;Volum 138.
    UiO NMBU 
     
     
    2. Fontaine, Romain; Hodne, Kjetil; Weltzien, Finn-Arne. 
    Healthy Brain-pituitary Slices for Electrophysiological Investigations of Pituitary Cells in Teleost Fish. Journal of Visualized Experiments 2018 
    NMBU 
     
    2017
    3. von Krogh, Kristine; Bjørndal, Gunnveig Toft; Nourizadeh-Lillabadi, Rasoul; Hodne, Kjetil; Ropstad, Erik; Haug, Trude M; Weltzien, Finn-Arne. 
    Sex steroids differentially regulate fshb, lhb and gnrhr expression in Atlantic cod (Gadus morhua). Reproduction 2017 ;Volum 154.(5) s. 581-594
    UiO NMBU 
    2016
    1. Hafver, Tandekile Lubelwana; Hodne, Kjetil; Wanichawan, Pimthanya; Aronsen, Jan Magnus; Dalhus, Bjørn; Lunde, Per Kristian; Lunde, Marianne; Martinsen, Marita; Enger, Ulla Helene; Fuller, William; Sjaastad, Ivar; Louch, William Edward; Sejersted, Ole M; Carlson, Cathrine Rein. 
    Protein phosphatase 1c associated with the cardiac sodium calcium exchanger 1 regulates its activity by dephosphorylating Serine 68-phosphorylated phospholemman. Journal of Biological Chemistry 2016 ;Volum 291.(9) s. 4561-4579
    BJORKNES OUS UiO NMBU 
     
     
    2. Wanichawan, Pimthanya; Hodne, Kjetil; Hafver, Tandekile Lubelwana; Lunde, Marianne; Martinsen, Marita; Louch, William Edward; Sejersted, Ole M; Carlson, Cathrine Rein. 
    Development of a high affinity peptide that prevents phospholemman (PLM) inhibition of the sodium-calcium exchanger 1 (NCX1). Biochemical Journal2016 ;Volum 473. s. 2413-2423
    OUS UiO 
     
    2015
    3. Hafver, Tandekile Lubelwana; Hodne, Kjetil; Wanichawan, Pimthanya; Aronsen, Jan Magnus; Dalhus, Bjørn; Lunde, Per Kristian; Martinsen, Marita; Enger, Ulla Helene; Fuller, William; Louch, William Edward; Sejersted, Ole M; Carlson, Cathrine Rein. 
    PP1 associated with cardiac NCX1 regulates exchange activity by dephosphorylating pSer-68-PLM. 7th International Conference on Sodium Exchange; 2015-11-01 - 2015-11-05
    OUS UiO 
     
     
    4. Hafver, Tandekile Lubelwana; Wanichawan, Pimthanya; Hodne, Kjetil; Aronsen, Jan Magnus; Dalhus, Bjørn; Lunde, Marianne; Enger, Ulla Helene; Mathisen, Marita; Fuller, William; Sjaastad, Ivar; Sejersted, Ole M; Carlson, Cathrine Rein. 
    Anchoring onto NCX1 facilitates dephosphorylation of P-SER68-PLM. Biophysical Journal 2015 ;Volum 108. Suppl. 1 s. 584a-584a
    UiO 
     
     
    5. Hodne, Kjetil; Wanichawan, Pimthanya; Lubelwana, Tandekile; Louch, William Edward; Lunde, Marianne; Mathisen, Marita; Sejersted, Ole M; Carlson, Cathrine Rein. 
    Liberation of Pser68-Plm inhibition of NCX1 by an optimized anchoring disruptor peptide. Biophysical Journal 2015 ;Volum 108. Suppl. 1 s. 434a-434a
    OUS UiO 
     
     
    6. Hodne, Kjetil; Weltzien, Finn-Arne. 
    Single-cell isolation and gene analysis: Pitfalls and possibilities. International Journal of Molecular Sciences 2015 ;Volum 16.(11) s. 26832-26849
    NMBU 
     
     
    7. Wanichawan, Pimthanya; Hodne, Kjetil; Hafver, Tandekile Lubelwana; Lunde, Marianne; Martinsen, Marita; Louch, William Edward; Sejersted, Ole M; Carlson, Cathrine Rein. 
    Development of a high affinity phospholemman binding peptide that reverses phosphorylated serine 68 phospholemman inhibition of the cardiac sodium-calcium exchanger 1. 7th International Conference on Sodium Exchange; 2015-11-01 - 2015-11-05
    OUS UiO 
     
    2014
    8. Hafver, Lubelwana; Wanichawan, Pimthanya; Hodne, Kjetil; Aronsen, Jan Magnus; Dalhus, Bjørn; Lunde, Marianne; Mathisen, M; Sjaastad, Ivar; Sejersted, Ole M; Carlson, Cathrine Rein. 
    Molecular analysis of the phospho-PLM-NCX1-PP1 complex. 12th Annual CHFR on Heart Failure; 2014-09-17 - 2014-09-19
    OUS UiO 
     
     
    9. Hafver, Tandekile Lubelwana; Wanichawan, Pimthanya; Hodne, Kjetil; Aronsen, Jan Magnus; Dalhus, Bjørn; Lunde, Marianne; Martinsen, Marita; Sjaastad, Ivar; Sejersted, Ole M; Carlson, Cathrine Rein. 
    Molecular analysis of PP1 anchoring to NCX1 macromolecular complex. 15th Annual SA Heart Congress; 2014-10-16 - 2014-10-19
    BJORKNES OUS UiO NMBU 
     
     
    10. Hafver, Tandekile Lubelwana; Wanichawan, Pimthanya; Hodne, Kjetil; Aronsen, Jan Magnus; Dalhus, Bjørn; Lunde, Marianne; Martinsen, Marita; Sjaastad, Ivar; Sejersted, Ole M; Carlson, Cathrine Rein. 
    Molecular analysis of the pPLM-NCX1-PP1 complex. FASEB_PROTEIN PHOSPHATASES CONFERENCE; 2014-07-20 - 2014-07-25
    BJORKNES OUS UiO NMBU 
     
     
    11. Hodne, Kjetil; Wanichawan, Pimthanya; Hafver, Tandekile Lubelwana; Aronsen, Jan Magnus; Lunde, Ida Gjervold; Lunde, Marianne; Kvaløy, Heidi; Tønnessen, Theis; Sjaastad, Ivar; Louch, William Edward; Sejersted, Ole M; Carlson, Cathrine Rein. 
    Identification and functional role of calpain cleavage site in Na+-Ca2+ exchanger 1 (NCX1). Biophysical Journal 2014 ;Volum 106. Suppl. 1 s. 762a-
    OUS UiO 
     
     
    12. Lipsett, David Bruce; Frisk, Michael; Hodne, Kjetil; Singh, Neha; Nygård, Ståle; Aronsen, Jan Magnus; Sejersted, Ole M; Sjaastad, Ivar; Wasserstrom, Andrew J.; Christensen, Geir Arve; Louch, William Edward. 
    B1N1 controls longitudinal T-tubule growth in cardiomyocytes during development and disease. 12th Annual CHFR on Heart Failure; 2014-09-17 - 2014-09-19
    BJORKNES OUS UiO 
     
     
    13. Sandvik, Guro Katrine; Hodne, Kjetil; Haug, Trude M; Okubo, Kataaki; Weltzien, Finn-Arne. 
    RFamide peptides in early vertebrate development. Frontiers in Endocrinology 2014 ;Volum 5:203.
    OUS UiO NMBU 
     
     
    14. Wanichawan, Pimthanya; Hodne, Kjetil; Hafver, Lubelwana; Lunde, Marianne; Sejersted, Ole M. 
    Identification and optimization of PLM binding sequences in NCX1. 12th Annual Sympsium Center for Heart Failure Research; 2014-09-17 - 2014-09-19
    OUS UiO 
     
     
    15. Wanichawan, Pimthanya; Lubelwana, Tandekile; Hodne, Kjetil; Aronsen, Jan Magnus; Lunde, Ida Gjervold; Dalhus, Bjørn; Lunde, Marianne; Kvaløy, Heidi; Louch, William Edward; Tønnessen, Theis; Sjaastad, Ivar; Sejersted, Ole M; Carlson, Cathrine Rein. 
    Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure. Journal of Biological Chemistry 2014 ;Volum 289.(49) s. 33984-33998
    BJORKNES OUS UiO 
     
     
    16. Weltzien, Finn-Arne; Hildahl, Jon Paul; Hodne, Kjetil; Okubo, Kataaki; Haug, Trude M. 
    Embryonic development of gonadotrope cells and gonadotropic hormones - Lessons from model fish. Molecular and Cellular Endocrinology 2014 ;Volum 385.(1-2) s. 18-27
    UiO NMBU 
     
     
    17. Weltzien, Finn-Arne; Hildahl, Jon Paul; Hodne, Kjetil; Okubo, Kataaki; Haug, Trude M. 
    Embryonic development of gonadotrope cells and gonadotropic hormones - Lessons from model fish. Molecular and Cellular Endocrinology 2014 ;Volum 385. s. 18-27
    UiO NMBU 
     
    2013
    18. Hodne, Kjetil; Strandabø, Rønnaug; von Krogh, Kristine; Nourizadeh-Lillabadi, Rasoul; Sand, Olav; Weltzien, Finn-Arne; Haug, Trude M. 
    Electrophysiological differences between fshb- and lhb-expresing gonadotropes in primary culture. Endocrinology 2013 ;Volum 154.(9) s. 3319-3330
    UiO NMBU 
     
     
    19. Hodne, Kjetil; Weltzien, Finn-Arne; Oka, Y; Okubo, K. 
    Expression and Putative Function of Kisspeptins and Their Receptors During Early Development in Medaka. Endocrinology 2013 ;Volum 154.(9) s. 3437-3446
    UiO NMBU 
     
     
    20. Strandabø, Rønnaug; Hodne, Kjetil; Ager-Wick, Eirill; Sand, Olav; Weltzien, Finn-Arne; Haug, Trude M. 
    Signal transduction involved in GnRH2-stimulation of identified LH-producing gonadotropes from lhb-GFP transgenic medaka (Oryzias latipes). Molecular and Cellular Endocrinology 2013 ;Volum 372.(1-2) s. 128-139
    UiO NMBU 
     
    2012
    21. Hildahl, Jon Paul; Sandvik, Guro Katrine; Lifjeld, Rikke; Hodne, Kjetil; Nagahama, Y; Haug, Trude M; Okubo, Kataaki; Weltzien, Finn-Arne. 
    Developmental Tracing of Luteinizing Hormone b-Subunit Gene Expression Using Green Fluorescent Protein Transgenic Medaka (Oryzias latipes) Reveals a Putative Novel Developmental Function. Developmental Dynamics 2012 ;Volum 241.(11) s. 1665-1677
    UiO NMBU 
     
     
    22. Hodne, Kjetil; von Krogh, Kristine; Weltzien, Finn-Arne; Sand, Olav; Haug, Trude M. 
    Optimized conditions for primary culture of pituitary cells from the Atlantic cod (Gadus morhua). The importance of osmolality, pCO(2), and pH. General and Comparative Endocrinology 2012 ;Volum 178.(2) s. 206-215
    UiO NMBU 
     
    2010
    23. Hodne, Kjetil; Haug, Trude M; Weltzien, Finn-Arne. 
    Single-cell qPCR on dispersed primary pituitary cells -an optimized protocol. BMC Molecular Biology 2010 ;Volum 11. s. -
    UiO NMBU 
     
    2007
    24. Haug, Trude M; Hodne, Kjetil; Weltzien, Finn-Arne; Sand, Olav. 
    Electrophysiological properties of pituitary cells in primary culture from Atlantic cod (Gadus morhua). Neuroendocrinology 2007 ;Volum 86. s. 38-47
    UiO 
     
     
    25. Haug, Trude M; Hodne, Kjetil; Weltzien, Finn-Arne; Sand, Olav. 
    Signaling properties of teleost gonadotropes with a first study from atlantic cod. Acta Physiologica 2007 ;Volum 190. Suppl. 656 s. 504-
    UiO 
     
    2006
    26. Haug, Trude M; Hodne, Kjetil; Weltzien, Finn-Arne; Sand, Olav. 
    Electrophysiological properties of pituitary cells in primary cultures from atlantic cod (Gadus morhua). Acta Physiologica 2006 ;Volum 187. Suppl. 659 s. P23-
    UiO 
     
  • Undervisning

    I teach veterinary students and veterinary nurse students in muscle physiology.

  • Forskning og prosjekter

    Forskningsprosjekter med nettside utenfor NMBU

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